Publications


Publications and Preprints:
27) Burke, Emily K.;  Robertson, Katherine N.; Speed, Alexander W. H.* "Convenient Lanthanum-Mediated Synthesis of Bulky tert-Alkyl Amines from Nitriles." Chem. Commun, Just Accepted





26) Burke, Emily K.; Welsh, Erin N.; Robertson, Katherine N.; Speed, Alexander W. H.* "Efficient Synthesis and Functionalization of 3-Bromo Naphtho[2,3b]thiophene." Synthesis 2023, 55, 2406–2414.



25) Welsh, Erin N.; Robertson, Katherine N.; Speed, Alexander W. H.* "Gram-Scale Synthesis of the N-Phenyl Phenothiazine Photocatalyst by Benzyne Addition" Can. J. Chem. 2022, 100, 809–813.



24) Riley, Robert D.; Huchenski, B. S. N.; Bamford, Karlee L.; Speed, Alexander W. H.* "Inter and Intramolecular Radical Additions of Aryl Halides Catalyzed by Diazaphospholenes" Angew. Chem., Int. Ed. 2022, 61, e202204088




23) Huchenski, Blake S. N.; Speed, Alexander W. H.  "Room-Temperature Reduction of Sulfur Hexafluoride with Metal Phosphides." Chem. Commun. 2021, 57, 7128–7131.



22) Welsh, Erin N.; Robertson, Katherine N.; Speed, Alexander W. H. "Short Synthesis of 1-Substituted Dibenzothiophene Derivatives." Org. Biomol. Chem. 2021,  19, 2000–2007.



A pre-print was published in 2019 that contained portions of this work: Welsh, Erin N.; Burke, Emily K.; Robertson, Katherine N.; Speed, Alexander W. H. "Short Syntheses of 1-Substituted Dibenzothiophenes and 3-Substituted Naphthothiophenes." 

21) Speed, Alexander W. H. "Applications of diazaphospholene hydrides in chemical catalysis." Chem. Soc. Rev. 2020, 49, 8335–8353.



20) Huchenski, Blake, S. N.; Robertson, Katherine N.; Speed, Alexander W. H. "Functionalization of Bis-Diazaphospholene P-P Bonds with Diverse Electrophiles." Eur. J. Org. Chem. 2020, 5140–5144.


https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.202000880

Preprint: https://chemrxiv.org/articles/Functionalization_of_Bis-Diazaphospholene_P-P_Bonds_with_Diverse_Electrophiles/12152835

19) Lundrigan, Travis; Tien, Chieh-Hung; Robertson, Katherine N.; Speed, Alexander W. H. "Air and Water Stable Secondary Phosphine Oxides as Diazaphospholene Precatalysts." Chem. Commun. 2020, 56, 8027–8030.

18) Hynes, Toren.; Hall, David S.; Speed, Alexander W. H.; Masuda, Jason D.; Dahn, Jeff. "A one-pot method for the synthesis of 3-(hetero-)aryl-1,4,2-dioxazol-5-ones" Can. J. Chem. 2020

https://www.nrcresearchpress.com/doi/abs/10.1139/cjc-2019-0419

17) Lundrigan, Travis; Welsh, Erin N.; Hynes, Toren; Tien, Chieh-Hung; Adams, Matt R.; Roy, Kayelani, R.; Robertson Katherine, N.; Speed, Alexander, W. H. "Enantioselective Imine Reduction Catalyzed by Phosphenium Ions." J. Am. Chem. Soc. 2019, 141, 14083–14088.



https://pubs.acs.org/doi/pdf/10.1021/jacs.9b07293?rand=fqvtm5xg

16) Guild, Jonathan; Morris, Michael J.; Robertson, Craig C.; Speed, Alexander W. H. "One-pot synthesis of new iso-DPP derivatives from terminal alkynes and isocyanates" Tetrahedron Lett. 2019, 39, 151079.

https://www.sciencedirect.com/science/article/pii/S0040403919308421

15) Huchenski, Blake S. N.; Christopherson, Cheyenne J.; Robertson, Katherine N.; Speed, Alexander W. H. "Bis-aminocyclopropenylidene Carbene Borane Catalyzed Imine Hydrogenation." Org. Biomol. Chem. 2019, 17, 6158–6164.
https://pubs.rsc.org/en/content/articlelanding/2019/ob/c9ob01053j#!divAbstract

14) Huchenski, Blake, S. N.; Speed, Alexander W. H.
"Protic Additives or Impurities Promote Imine reduction With Pinacolborane." Org. Biomol. Chem. 2019, 17, 1999–2004.

https://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB02330A

13) Cuthbert, Tyler J.; Li, Tong, Speed, Alexander W. H.; Wulff, Jeremy E. "Structure of the Thermally Induced Cross-Link in C-Linked Methyl Ester-Functionalized Polydicyclopentadiene (fPDCPD)" Macromolecules 2018, 51, 2038–2047.

12) Gatien, Alexandre; Lavoie, Christopher M.; Bennett, Raymond, N.; Ferguson, Michael J.; McDonald, Robert, Johnson, Erin, R.; Speed, Alexander W. H.; Stradiotto, Mark. "Application of Diazaphospholidine/Diazaphospholene-Based Bisphosphines in Room Temperature Nickel-Catalyzed C(sp2)-N Cross-Couplings of Primary Alkylamines with Hetero(aryl) Chlorides and Bromides." ACS Catal. 2018, 8, 5328–5339.


https://pubs.acs.org/doi/10.1021/acscatal.8b01005

11)  Hynes, Toren; Welsh, Erin N.; McDonald, Robert, Ferguson, Michael J.; Speed, Alexander W. H.
"Pyridine Hydroboration with a Diazaphospholene Precatalyst." Organometallics 2018, 37, 841–844.


https://pubs.acs.org/doi/abs/10.1021/acs.organomet.8b00028

10) Adams, Matt R.; Tien, Chieh Hung; McDonald, Robert; Speed, Alexander W. H.
"Asymmetric Imine Hydroboration Catalyzed by Chiral Diazaphospholenes." Angew. Chem., Int. Ed. 2017, 56, 16660–16663.


http://onlinelibrary.wiley.com/doi/10.1002/anie.201709926/full

9)  Tien, Chieh Hung; Adams, Matt R.; Ferguson, Michael J.; Johnson, Erin R.; Speed, Alexander W. H. "Hydroboration Catalyzed by 1,2,4,3 Triazaphospholenes." Org. Lett. 2017, 19, 5565–5568.


http://pubs.acs.org/doi/full/10.1021/acs.orglett.7b02695

8) Adams, Matt R.; Tien, Chieh Hung; Huchenski, Blake S. N.; Ferguson, Michael J.; Speed, Alexander W. H. "Diazaphospholene Precatalysts for Imine and Conjugate Reductions." Angew. Chem., Int. Ed. 2017, 56, 6268–6271. 


https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201611570

7) Shen, Xiao.; Nguyen, Thach T.; Koh, Ming Joo; Xu, Dongmin; Speed, Alexander W. H., Schrock, Richard R.; Hoveyda, Amir H. "Kinetically E-selective macrocyclic ring closing metathesis." Nature 2017, 541, 380–385.

https://www.nature.com/articles/nature20800

6) Huchenski, Blake S. N.; Adams, Matt R.; McDonald, Robert; Ferguson, Michael J.; Speed, Alexander, W. H. "Synthesis and Catalytic Reactivity of Bis(amino)cyclopropenylidene Carbene–Borane Adducts." Organometallics 2016, 35, 3101–3104.


http://pubs.acs.org/doi/abs/10.1021/acs.organomet.6b00654



Before 2015:



 5) Speed, Alexander W. H.; Mann, Tyler J.; O’Brien, Robert V. III; Schrock, Richard R.; Hoveyda, Amir H. “Catalytic Z-Selective Cross-Metathesis in Complex Molecule Synthesis: A Convergent Stereoselective Route to Disorazole C1.” J. Am. Chem. Soc. 2014, 136, 16136–16139.

 https://pubs.acs.org/doi/abs/10.1021/ja509973r


4)     Mann, Tyler J.; Speed, Alexander W. H.; Schrock, Richard R.; Hoveyda, Amir H. “Catalytic Z- Selective Cross-Metathesis with Secondary Silyl- and Benzyl-Protected Allylic Ethers: Mechanistic Aspects and Applications to Natural Product Synthesis.” Angew. Chem., Int. Ed. 2013, 52, 8395–8400.

 https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201302538

 3)     Marcoux, David; Bindschädler, Pascal; Speed, Alexander W. H.; Chiu, Anna;  Pero, Joseph, E.; Borg, George A.;  Evans, David A. “Effect of Counterion Structure on the Rates and Diastereoselectivities in a,b- Unsaturated Iminium-Ion Diels- Alder Reactions.” Org. Lett. 2011, 13, 3758–3761.

 https://pubs.acs.org/doi/abs/10.1021/ol201448h

2)     Evans, David A.; Welch, Dennie S.; Speed, Alexander W. H.; Moniz, George A.; Reichelt, Andreas.; Ho, Stephen.  “An Aldol-Based Synthesis of (+)-Peloruside A, A Potent Microtubule Stabilizing Agent.” J. Am. Chem. Soc. 2009, 131, 3840–3841.

 https://pubs.acs.org/doi/10.1021/ja900020a

1)     Pincock, J.A.; Speed, A.W.H. “Aromatic character and resonance stabilization energy of substituted cyclopentadienyl and indenyl cations.” Can. J. Chem. 2005, 83, 1287–1298.

 https://www.nrcresearchpress.com/doi/10.1139/v05-137#.Xcf0qZJKjL8



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